Duke University School of Medicine and Duke Health are harnessing the power of artificial intelligence (AI) to enhance various aspects of healthcare. From optimizing surgery schedules to providing instant feedback on academic writing for students and accelerating drug discovery, these AI applications are tailored to specific tasks, ensuring their trustworthiness in healthcare. In an article recently published in DukeMed Alumni News, Duke Health’s Michael Pencina, PhD, and Nicoleta Economou, PhD, emphasize the importance of AI serving humans, stating that while powerful, it is ultimately a tool grounded in mathematics. The article by Angela Spivey highlights the Duke team's innovative approach that extends to creating diverse and equitable AI algorithms, acknowledging the crucial role of human involvement in designing and implementing these technologies.