The Coalition for Health AI (CHAI) has released its highly anticipated “Blueprint for Trustworthy AI Implementation Guidance and Assurance for Healthcare." The Blueprint addresses the quickly evolving landscape of health AI tools by outlining specific recommendations to increase trustworthiness within the healthcare community, ensure high-quality care, and meet healthcare needs. The 24-page guide reflects a unified effort among subject matter experts from leading academic medical centers and the healthcare, technology, and other industry sectors, who collaborated under the observation of several federal agencies over the past year. As founding members of CHAI, members of the Duke AI Health team were key contributors to the Blueprint.