A new Viewpoint in JAMA Health Forum by Duke’s Michael Pencina, Mark McClellan, and colleagues lays out a pragmatic blueprint for aligning U.S. health AI policy with clinical realities. While current regulations emphasize innovation and safety, the authors propose leveraging third-party enablers such as accreditation bodies, public-private partnerships, and data collaboratives to clarify oversight roles, strengthen local AI governance, and support continuous evidence generation. The piece calls on the government to act as both funder and convener to accelerate scalable, flexible frameworks that responsibly bring AI from development to the bedside.